Chiu -Min Cheng, Ph.D.

1.International Journal Papers 1. Circular Economy and Sustainable Recovery of Taiwanese Tilapia (Oreochromis mossambicus) Byproduct-The Large-Scale Production of Umami-Rich Seasoning Material Application. Lin CH, Huang YT, Ciou JY, Cheng CM, Wang GT, You CM, Huang PH, *Hou CY. Foods. 2023 May 8;12 (9):1921.

2. ERCC1 Overexpression Increases Radioresistance in Colorectal Cancer Cells. Huang YJ, Huang MY, Cheng TL, Kuo SH, Ke CC, Chen YT, Hsieh YC, Wang JY, Cheng CM, *Chuang CH. Cancers (Basel). 2022 Sep 30;14(19):4798.

3. HIF-1α Expression Increases Preoperative Concurrent Chemoradiotherapy Resistance in Hyperglycemic Rectal Cancer. Huang YJ, Chen YT, Huang CM, Kuo SH, Liao YY, Jhang WY, Wang SH, Ke CC, Huang YH, Cheng CM, Huang MY, *Chuang CH. Cancers (Basel). 2022 Aug 22;14(16):4053.

4. Evaluation of Clove Extract for Drug Therapy of Ciliate Infection in Coral (Goniopora columna).Chu TW, Cheng CM, Cheng YR, Dong CD, Chuang CH, Pan CH, Sun WT, *Ding DS. Biology (Basel). 2022 Feb 10;11(2):280.

5. Effects of LED Light Illumination on the Growth, Digestive Enzymes, and Photoacclimation of Goniopora columna in Captivity. Cheng CM, Cheng YR, Lin HY, Sun WT, Pan CH, *Ding DS. Animals (Basel). 2022 Jan 26;12(3):306.

6. Separation and Identification of Resveratrol Butyrate Ester Complexes and Their Bioactivity in HepG2 Cell Models.Shih MK, Tain YL, Cheng CM, Hsu CN, Chen YW, Huang HT, Chang CI, Hou CY. International Journal of Molecular Science. 2021 Dec 7;22(24):13539.

7. Effect of cell-permeable grouper Manganese Superoxide Dismutase on environmental stress in fish. Chuang HC, Ding DS, Fan CH, Lin CH, *Cheng CM. Protein Expression and Purification. 2021 Nov;187:105951.

8. Effects of Ciliate Infection on the Activities of Two Antioxidant Enzymes (SOD and CAT) in Captive Coral (Goniopora columna) and Evaluation of Drug Therapy.Cheng CM, Cheng YR, Ding DS, Chen YT, Sun WT, Pan CH. Biology (Basel). 2021 Nov 21;10(11):1216.

9. Heterologous expression of bacterial CotA-laccase, characterization and its application for biodegradation of malachite green. Cheng CM, Patel AK, Singhania RR, Tsai CH, Chen SY, Chen CW, *Dong CD. Bioresource Technology. 2021 Nov; 340:125708.

10. Developing a Virus-Binding Bacterium Expressing Mx Protein on the Bacterial Surface to Prevent Grouper Nervous Necrosis Virus Infection.Lin CH, Chen JJ, *Cheng CM. Journal of microbiology and biotechnology. 2021 Aug 28;31(8):1088-1097.

11. A southward range extension of a wreckfish, Stereolepis doederleini (Actinopterygii: Acropomatiformes: Polyprionidae), to tropical water off eastern Taiwan. Hsuan-Ching Ho, Chi-Ngai Tang, *Chiu-Min Cheng. Acta Ichthyologica et Piscatoria 51(4), 2021, 365–370.

12. Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy. Lin WW, Cheng YA, Li CC, Ho KW, Chen HJ, Chen IU, Huang BC, Liu HJ, Lu YC, Cheng CM, Huang MY, Lai HW, *Cheng TL. Sci Rep. 2021 Apr 7;11(1):7598.

13. Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein.Huang CC, Cheng KW, Hsieh YC, Lin WW, Cheng CM, Yuan SF, Chen IJ, Cheng YA, Lu YC, Huang BC, Tung YC, Cheng TL. Sci Rep. 2019 Jul 9;9(1):9931.

14. Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.Cheng KW, Tseng CH, Tzeng CC, Leu YL, Cheng TC, Wang JY, Chang JM, Lu YC, Cheng CM, Chen IJ, Cheng YA, Chen YL, *Cheng TL. Pharmacol Res. 2019 Jan;139:41-49.

15. Development of Membrane-Bound GM-CSF and IL-18 as an Effective Tumor Vaccine.Huang CC, Kuo KK, Cheng TC, Chuang CH, Kao CH, Hsieh YC, Cheng KH, Wang JY, Cheng CM, Chen CS, *Cheng TL. PLoS One. 2015 Jul 17;10(7):e0133470.

16. Impediments to enhancement of CPT-11 anticancer activity by E. coli directed beta-glucuronidase therapy.Hsieh YT, Chen KC, Cheng CM, *Cheng TL, Tao MH, Roffler SR.PLoS One. 2015 Feb 17;10(2):e0118028.

17. Functional production of a soluble and secreted single-chain antibody by a bacterial secretion system.Cheng CM, Tzou SC, Zhuang YH, Huang CC, Kao CH, Liao KW, Cheng TC, Chuang CH, Hsieh YC, Tai MH,  *Cheng TL. PLoS One. 2014 May 13;9(5):e97367.

18. Expression of β-glucuronidase on the surface of bacteria enhances activation of glucuronide prodrugs.Cheng CM, Chen FM, Lu YL, Tzou SC, Wang JY, Kao CH, Liao KW, Cheng TC, Chuang CH, Chen BM, Roffler S, *Cheng TL. Cancer Gene Ther. 2013 May;20(5):276-81. doi: 10.1038/cgt.2013.17. Epub 2013 Apr 19.PMID: 23598434

19. In vivo positron emission tomography imaging of protease activity by generation of a hydrophobic product from a noninhibitory protease substrate. Chuang CH, Chuang KH, Wang HE, Roffler SR, Shiea JT, Tzou SC, Cheng TC, Kao CH, Wu SY, Tseng WL, Cheng CM, Hou MF, Wang JM, *Cheng TL. Clin Cancer Res. 2012 Jan 1;18(1):238-47.

20. A regularly spaced and self-revealing protein ladder for anti-tag Western blot analysis.Kao CH, Cheng CM, Chuang KH, Chuang CH, Tzou SC, Cheng TC, Hsieh YC, Liao KW, Wang YM, Chang LS, Roffler SR, Chen FM, *Cheng TL. Anal Biochem. 2012 Dec 1;431(1):1-3.

21. Endocytosis of PEGylated agents enhances cancer imaging and anticancer efficacy.Chuang KH, Wang HE, Chen FM, Tzou SC, Cheng CM, Chang YC, Tseng WL, Shiea J, Lin SR, Wang JY, Chen BM, Roffler SR, *Cheng TL. Mol Cancer Ther. 2010 Jun;9(6):1903-12.

22. Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems. Cheng CM, Chu PY, Chuang KH, Roffler SR, Kao CH, Tseng WL, Shiea J, Chang WD, Su YC, Chen BM, Wang YM, *Cheng TL. Cancer Gene Ther. 2009 Jan;16(1):83-90.

23. Micro-PET imaging of beta-glucuronidase activity by the hydrophobic conversion of a glucuronide probe.Tzou SC, Roffler S, Chuang KH, Yeh HP, Kao CH, Su YC, Cheng CM, Tseng WL, Shiea J, Harm IH, Cheng KW, Chen BM, Hwang JJ, *Cheng TL, Wang HE.Radiology. 2009 Sep;252(3):754-62.

24. Tumor-targeting prodrug-activating bacteria for cancer therapy.Cheng CM, Lu YL, Chuang KH, Hung WC, Shiea J, Su YC, Kao CH, Chen BM, Roffler S, *Cheng TL. Cancer Gene Ther. 2008 Jun;15(6):393-401.

25. Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored beta-glucuronidase. Su YC, Chuang KH, Wang YM, Cheng CM, Lin SR, Wang JY, Hwang JJ, Chen BM, Chen KC, Roffler S, *Cheng TL. Gene Ther. 2007 Apr;14(7):565-74.

26. Synthesis and characterization of a new bioactivated paramagnetic gadolinium(III) complex [Gd(DOTA-FPG)(H2O)] for tracing gene expression. Chang YT, Cheng CM, Su YZ, Lee WT, Hsu JS, Liu GC, Cheng TL, *Wang YM. Bioconjug Chem. 2007 Nov-Dec;18(6):1716-27.

27. A membrane antibody receptor for noninvasive imaging of gene expression. Roffler SR, Wang HE, Yu HM, Chang WD, Cheng CM, Lu YL, Chen BM, *Cheng TL. Gene Ther. 2006 Mar;13(5):412-20.

28. Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines.Chuang KH, Cheng CM, Roffler SR, Lu YL, Lin SR, Wang JY, Tzou WS, Su YC, Chen BM, *Cheng TL. Bioconjug Chem. 2006 May-Jun;17(3):707-14.

29. Monoclonal antibody-based quantitation of poly(ethylene glycol)-derivatized proteins, liposomes, and nanoparticles. Cheng TL, Cheng CM, Chen BM, Tsao DA, Chuang KH, Hsiao SW, Lin YH, *Roffler SR. Bioconjug Chem. 2005 Sep-Oct;16(5):1225-31.

30. Hapten-directed targeting to single-chain antibody receptors.Cheng TL, Liao KW, Tzou SC, Cheng CM, Chen BM, *Roffler SR. Cancer Gene Ther. 2004 May;11(5):380-8.

2.National Conference Papers 1.蔡建霆、鄭秋敏(2024),絲藻活性分析及作為生長刺激素之研究,2024臺灣水產學會113年度學術論文發表會, 屏東, 中華民國, EP18.

2.張芸寧、鄭秋敏(2024),,豐年蝦耐久卵酒精萃取物的抗氧化活性及避免大鼠胃上皮黏膜細胞潰瘍發生的研究,2024臺灣水產學會113年度學術論文發表會, 屏東, 中華民國, EP11.

3.尤玟潔、范植軒、鄭秋敏(2021), Effect of cell-permeable grouper Manganese Superoxide Dismutase on environmental stress in fish, 2021臺灣海洋生物技術學會第五屆會員大會暨科技促進海洋生技產業升級研討會, 高雄,中華民國

4.陳俊傑、鄭秋敏(2014), 細菌膜表現神經壞死病毒結合蛋白以預防神經壞死症爆發, 2013臺灣水產學會學術論文發表會, 1/18/2014-1/18/2014, 嘉義, 中華民國, pp.114.

5.何政鴻、江秀稻、鄭秋敏(2014), 細菌表現白點病毒結合蛋白以抑制白點症爆發, 2013臺灣水產學會學術論文發表會, 1/18/2014-1/18/2014, 嘉義, 中華民國, pp.115.

3.Patents 1.Kaohsiung Medical University, Auto-developing and regularly-weighted protein molecular weight marker kit and method for preparing the same, 美國專利商標局US8791240 B2, 2014/7/29-2032/2/22.